A Synthesis of Formaldehyde-C14 1

Synthesis of D-Glucose-1-C14 and D-Mannose-1-C14

Heretofore, radiochemical yields of sugars position-labeled with carbon-14 have been only 5 to 10 percent. This paper reports an improved cyanohydrin synthesis, and the preparation of D-glucose-1-C and D-mannose-1-C from D-arabinose in yields of about 50 percent. Low yields in prior syntheses appear to have been due to several inefficient steps, and to the fact that extension of the carbon chai...

The synthesis of 17-(methyl-C14)-testosterone and 21-C14-progesterone.

The use of steroid hormones containing tagged atoms promises to have an important part in the study of their metabolism. The relative availability of radioactive Cl4 manufactured in the uranium chain-reacting pile at Oak Ridge has facilitated the synthesis of such compounds containing labeled carbon atoms (1). Through the cooperation of Dr. Konrad Dobriner of the Sloan-Kettering Institute for C...

The synthesis of 3,4-benzpyrene-5-C14 and of 2-acetylaminofluorene-9-C14.

Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture.

Previous work has shown that the activity of the melatonin-forming enzyme in the rat pineal gland is elevated in rats kept in continuous darkness as compared to those kept in continuous light. Information about environmental lighting reaches the pineal gland via nerves that liberate noradrenaline. Rat pineal glands in organ culture can form C(14)-melatonin from C(14)-tryptophan as follows: tryp...

A comparison of the oxidation of octanoate-1-C14, -7-C14, and butyrate-1-C14 by neoplastic and normal mouse tissues.

The degradation of fatty acids of the even series by animal tissues yields Ca fragments (metabolically, acetyl-S-CoA) which may undergo various condensation reactions. Condensation with oxalacetate to form citrate is the established mecha nism for entrance of €2fragments into the tricarboxylic acid cycle, where they are subsequently oxidized to COs (11, 17). Liver possesses the abil ity to fo...